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Systematic combinations of a large variety of peptides manufactured to customer specifications; can be used for target screening in research areas such as immunotherapy, vaccine development, drug discovery, and proteomics.
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A DNA sequence encoding the Influenza A virus ((A/Victoria/4897/2022 (H1N1)) Nucleoprotein / NP (EPI2603713) (Met1-Asn498) was expressed with a C-terminal polyhistidine tag followed by an AVI tag. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19) the respiratory illness responsible for the COVID-19 pandemic SARS-CoV-2 also known as 2019-nCoV is a positive-sense single-stranded RNA virus and is believed to have zoonotic origins and has close genetic similarity to bat coronaviruses The receptor binding domain (RBD) of spike protein of the SARS-CoV-2 virus binds Angiotensin-Converting Enzyme 2 (ACE2) to invade the host cells Based on structural biology studies the RBD can be oriented either in the up/standing or down/lying state with the up/standing state associated with higher pathogenicity
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BA 2 differs from BA 1 in its genetic sequence including some amino acid differences in the spike protein and other proteins Studies have shown that BA 2 has a growth advantage over BA 1 Studies are ongoing to understand the reasons for this growth advantage but initial data suggest that BA 2 appears inherently more transmissible than BA 1 which currently remains the most common Omicron sublineage reported This difference in transmissibility appears to be much smaller than for example the difference between BA 1 and Delta Further although BA 2 sequences are increasing in proportion relative to other Omicron sublineages (BA 1 and BA 1 1) there is still a reported decline in overall cases globally
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